HLA Antibody Detection in Organ Transplantation
نویسندگان
چکیده
منابع مشابه
HLA antibody analysis: sensitivity, specificity, and clinical significance in solid organ transplantation.
The clinical relevance of humoral allosensitization has gained a lot of attention in the last few years. An increasing number of studies have demonstrated adverse graft survival in patients who have either preformed or post-transplant-developed anti-HLA antibodies. The detection of HLA antibodies and the specificity analysis have evolved over time from primarily cell-based to solid-phase method...
متن کاملHLA antibody testing: a tool to facilitate not to prevent organ transplantation
The introduction of very sensitive HLA antibody screening assays has destroyed the old dogma that pre-existence of donor specific HLA antibodies in the patient is a contraindication for transplantation. The challenge is now to reach consensus on the parameters which predict the clinical relevance of donor specific HLA antibodies. Antibody screening assays should not only be used to prevent tran...
متن کاملA glow of HLA typing in organ transplantation
The transplant of organs and tissues is one of the greatest curative achievements of this century. In organ transplantation, the adaptive immunity is considered the main response exerted to the transplanted tissue, since the main goal of the immune response is the MHC (major histocompatibility complex) molecules expressed on the surface of donor cells. Cell surface molecules that induce an anti...
متن کاملUtility of HLA Antibody Testing in Kidney Transplantation.
HLA antigens are polymorphic proteins expressed on donor kidney allograft endothelium and are critical targets for recipient immune recognition. HLA antibodies are risk factors for acute and chronic rejection and allograft loss. Solid-phase immunoassays for HLA antibody detection represent a major advance in sensitivity and specificity over cell-based methods and are widely used in organ alloca...
متن کاملHLA Mismatching Strategies for Solid Organ Transplantation – A Balancing Act
HLA matching provides numerous benefits in organ transplantation including better graft function, fewer rejection episodes, longer graft survival, and the possibility of reduced immunosuppression. Mismatches are attended by more frequent rejection episodes that require increased immunosuppression that, in turn, can increase the risk of infection and malignancy. HLA mismatches also incur the ris...
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ژورنال
عنوان ژورنال: Major Histocompatibility Complex
سال: 2013
ISSN: 2186-9995,2187-4239
DOI: 10.12667/mhc.20.121